(12459+49008+24576)-(5346+5347+5348)

Let's break down the calculation step by step.

First, we calculate the sum of the numbers in the first parenthesis:

\[ 12459 + 49008 + 24576 = 86043 \]

Next, we calculate the sum of the numbers in the second parenthesis:

\[ 5346 + 5347 + 5348 = 16041 \]

Now we subtract the sum of the second parenthesis from the sum of the first parenthesis:

\[ 86043 - 16041 = 70002 \]

So, the final answer is:

\[ \boxed{70002} \]