-4•(5+4x)

To simplify the expression \(-4 \cdot (5 + 4x)\), apply the distributive property:

\[ -4 \cdot (5) + (-4) \cdot (4x) \]

Calculating each term:

1. \(-4 \cdot 5 = -20\)
2. \(-4 \cdot 4x = -16x\)

Putting it all together, you get:

\[ -20 - 16x \]

So, the simplified expression is:

\[ -20 - 16x \]