18х3у2z*(-2/9xy2zx2)*(-2xyzxyx)=

To simplify the expression \( 18x^3y^2z \cdot \left(-\frac{2}{9}xy^2zx^2\right) \cdot (-2xyzxyx) \), we proceed step by step.

1. Combine the constants:

   • Constant terms: \( 18 \cdot \left(-\frac{2}{9}\right) \cdot (-2) \)

   First, simplify the constants:

   \[ 18 \cdot \left(-\frac{2}{9}\right) = -\frac{36}{9} = -4 \]

   Now, multiplying by \(-2\):

   \[ -4 \cdot -2 = 8 \]

2. Combine the variable parts:

   Now let’s combine the variable parts:

   \[ x^3 \cdot x \cdot x = x^{3+1+1} = x^5 \]

   \[ y^2 \cdot y^2 \cdot y \cdot y = y^{2+2+1+1} = y^6 \]

   \[ z \cdot z \cdot z = z^{1+1+1} = z^3 \]

3. Putting it all together:

   Now combine the constant and variable parts together:

   \[ 8 \cdot x^5 \cdot y^6 \cdot z^3 = 8x^5y^6z^3 \]

Thus, the simplified expression is:

\[ \boxed{8x^5y^6z^3} \]