4225:65+75•2454-330078:813

To solve the expression \( 4225:65 + 75 \cdot 2454 - 330078:813 \), we need to follow the order of operations (PEMDAS/BODMAS):

1. Division and Multiplication from left to right.
2. Addition and Subtraction from left to right.

Let's calculate it step by step:

1. Calculate divisions:

   • \( 4225 \div 65 = 65 \) (since \( 4225 = 65 \cdot 65 \))
   • \( 330078 \div 813 = 405 \)

2. Calculate multiplication:

   • \( 75 \cdot 2454 = 183900 \)

Now substitute back into the expression:

\[ 65 + 183900 - 405 \]

3. Perform addition and subtraction:
   • \( 65 + 183900 = 183965 \)
   • \( 183965 - 405 = 183560 \)

The final result is:

\[ \boxed{183560} \]