452-(52+300)=

To solve the expression \( 452 - (52 + 300) \), first calculate the sum inside the parentheses:

\[ 52 + 300 = 352 \]

Now, replace the parentheses in the original expression:

\[ 452 - 352 \]

Next, perform the subtraction:

\[ 452 - 352 = 100 \]

Thus, the final answer is:

\[ 100 \]