46-33*99/1-3

To solve the expression \( 46 - 33 \times 99 / 1 - 3 \), we will follow the order of operations (PEMDAS/BODMAS):

1. Multiplication and Division from left to right
2. Addition and Subtraction from left to right

Let's break it down step by step:

1. Calculate \( 33 \times 99 \): \[ 33 \times 99 = 3267 \]

2. Now, divide by \( 1 \): \[ 3267 / 1 = 3267 \]

3. Now substitute back into the expression: \[ 46 - 3267 - 3 \]

4. First, perform \( 46 - 3267 \): \[ 46 - 3267 = -3221 \]

5. Lastly, subtract \( 3 \): \[ -3221 - 3 = -3224 \]

Thus, the final answer is: \[ \boxed{-3224} \]