-3×(45+108)

To solve the expression \(-3 \times (45 + 108)\), we first need to calculate the sum inside the parentheses:

\[ 45 + 108 = 153 \]

Now, multiply this result by \(-3\):

\[ -3 \times 153 = -459 \]

Therefore, \(-3 \times (45 + 108) = -459\).