2xy - 9x2y3 + 4x +5y3x2 - 10x + 1.

To simplify the expression \( 2xy - 9x^2y^3 + 4x + 5y^3x^2 - 10x + 1 \), we can combine like terms.

Let's rearrange the terms to group them:

\[ (2xy) + (-9x^2y^3 + 5y^3x^2) + (4x - 10x) + 1 \]

Now, simplify:

1. Combine the \( x \) terms: \[ 4x - 10x = -6x \]

2. The \( y^3x^2 \) terms can be combined: \[ -9x^2y^3 + 5y^3x^2 = (-9 + 5)x^2y^3 = -4x^2y^3 \]

Now, we can rewrite the expression:

\[ 2xy - 4x^2y^3 - 6x + 1 \]

So, the simplified expression is:

\[ -4x^2y^3 + 2xy - 6x + 1 \]