It looks like you're presenting an equation or an expression that needs simplification or evaluation. However, the notation you've used seems a bit unclear. Let’s try to interpret it.
It seems like you might be trying to work with a mathematical expression involving numbers separated by commas and mathematical operations. Based on common mathematical operations, let's break it down:
The expression "1 - 4, 8^2 + 1 - 4, 8 + 1" seems to deal with the numbers in what could be sets of operations.
If we consider "4,8" as two separate numbers, the expression might then be interpreted as:
\( 1 - 4 + 8^2 + 1 - 4 + 8 + 1 \)
Now let's simplify that step-by-step:
Calculate \( 8^2 \): \[ 8^2 = 64 \]
Now substitute back into the expression: \[ 1 - 4 + 64 + 1 - 4 + 8 + 1 \]
Combine the constants: \[ (1 + 1 + 1) + (64) + (8) - (4 + 4) \] \[ = 3 + 64 + 8 - 8 \]
Combine further: \[ = 3 + 64 + 0 = 67 \]
So, the entire expression evaluates to \( 67 \).
If your original notation or intention was different, please clarify so I can assist you better!