38*(-8)-(-40)*(-3)

To solve the expression \(38 \times (-8) - (-40) \times (-3)\), we will evaluate each part step by step.

1. Calculate \(38 \times (-8)\): \[ 38 \times (-8) = -304 \]

2. Calculate \(-(-40) \times (-3)\): \[ -40 \times (-3) = 120 \] Because multiplying two negative numbers results in a positive number.

3. Now substitute these results back into the expression: \[ -304 - 120 \]

4. Finally, perform the subtraction: \[ -304 - 120 = -424 \]

So, the final result is \(-424\).