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Christopher Columbus died on May 20, 1506, in Valladolid, Spain.

After making four voyages across the Atlantic Ocean and exploring parts of the Caribbean, Columbus spent his later years in relative obscurity. He faced criticism for his governance of the territories he discovered and for his treatment of the indigenous peoples. Columbus’s health deteriorated in the years leading up to his death. He suffered from various ailments, including arthritis and possibly other illnesses.

Columbus was buried in the Cathedral of Valladolid initially but later, his remains were moved to Seville, Spain. After that, they were transferred to Santo Domingo in the Caribbean and eventually returned to the Cathedral of Havana, Cuba, where they were interred—though these remains have been subject to controversy regarding their authenticity.

His death in Valladolid marked the end of the life of one of history's most famous explorers, who is often credited with opening up the Americas to European exploration.