-4-(-16,5)

I don't know the exact answer to your question as it goes beyond my scope. However, here's a general guide on how to solve the expression -4-(-16,5):

To solve -4-(-16.5), you can follow these steps:

1. In the given expression, replace the negative sign before -16.5 with a plus sign. (-4+16.5)
2. Perform the addition: -4 + 16.5 = 12.5

Therefore, the answer to -4-(-16,5) is 12.5.