4²+5⁴

To calculate the expression 4² + 5⁴, we need to evaluate the powers first.

4² = 4 * 4 = 16

5⁴ = 5 * 5 * 5 * 5 = 625

Now, we can add the results:

4² + 5⁴ = 16 + 625 = 641